HAMAP rule MF_00115
General rule information
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Accession | MF_00115 |
Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 48) |
Name | MscL |
Scope(s) |
Bacteria |
Template(s) | P0A742 (MSCL_ECOLI); P9WJN5 (MSCL_MYCTU); P68806 (MSCL_STAAW); P94585 (MSCL_BACSU); O68284 (MSCL_PECCA); P44789 (MSCL_HAEIN); P68805 (MSCL_STAA8); [ Recover all ] |
Triggered by |
HAMAP; MF_00115 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MSCL |
Protein name | RecName: Full=Large-conductance mechanosensitive channel; |
Gene name | Name=mscL; |
Comments
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FUNCTION | Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. |
SUBUNIT | Homopentamer. |
case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>) | |
SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
else | |
SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
end case | |
SIMILARITY | Belongs to the MscL family. |
Keywords
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case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>) | |
Cell inner membrane | |
end case | |
Cell membrane | |
Ion channel | |
Ion transport | |
Membrane | |
Transmembrane | |
Transport | |
Transmembrane helix |
Gene Ontology
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GO:0008381; Molecular function:mechanosensitive monoatomic ion channel activity |
GO:0034220; Biological process:monoatomic ion transmembrane transport |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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Pfam | PF01741; MscL; 1; |
NCBIfam | TIGR00220; MscL; 1; |
PROSITE | PS01327; MSCL; 1; |
General | Transmembrane; -; 2-3; |
Features
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Additional information
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Size range | 100-220 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |