HAMAP rule MF_00124
General rule information
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| Accession | MF_00124 |
| Dates | 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 24) |
| Name | Thymidine_kinase |
| Scope(s) |
Archaea Bacteria |
| Template(s) | Q97F65 (KITH_CLOAB); Q9PPP5 (KITH_UREPA); P23331 (KITH_ECOLI); Q81JX0 (KITH_BACAN); Q814U0 (KITH_BACCR); Q9WYN2 (KITH_THEMA); [ Recover all ] |
| Triggered by |
HAMAP; MF_00124 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | KITH |
| Protein name | RecName: Full=Thymidine kinase; EC=2.7.1.21; |
| Gene name | Name=tdk; |
Comments
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| CATALYTIC ACTIVITY | Reaction=ATP + thymidine = ADP + dTMP + H(+); Xref=Rhea:RHEA:19129, ChEBI:CHEBI:15378, ChEBI:CHEBI:17748, ChEBI:CHEBI:30616, ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=2.7.1.21; |
| SUBUNIT | Homotetramer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the thymidine kinase family. |
Keywords
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| Cytoplasm | |
| Transferase | |
| Kinase | |
| DNA synthesis | |
| ATP-binding | |
| Nucleotide-binding | |
| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| end case | |
Gene Ontology
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| GO:0005524; Molecular function:ATP binding | |
| GO:0004797; Molecular function:thymidine kinase activity | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
| GO:0006259; Biological process:DNA metabolic process | |
| GO:0005737; Cellular component:cytoplasm | |
Cross-references
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Features
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| From: KITH_CLOAB (Q97F65) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 15 | 22 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[GSA]-x(4)-G-K-[ST] | ||||||||
| BINDING | 88 | 91 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[DE]-E-x-[QHN] | ||||||||
| ACT_SITE | 89 | 89 | /note="Proton acceptor" | E | ||||||||
| BINDING | 145 | 145 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 148 | 148 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 183 | 183 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 186 | 186 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
[CH] | 1 | |||||||
Additional information
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| Size range | 184-227 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | There is a divergent tdk in a Bacillus natto plasmid (O52951) |