HAMAP rule MF_00190
General rule information
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Accession | MF_00190 |
Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 40) |
Name | Cardiolipin_synth_ClsA |
Scope(s) |
Bacteria Pseudomonadota |
Template(s) | P0A6H8 (CLSA_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00190 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | CLSA |
Protein name | RecName: Full=Cardiolipin synthase A; Short=CL synthase; EC=2.7.8.-; |
Gene name | Name=clsA; |
Comments
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FUNCTION | Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. |
CATALYTIC ACTIVITY | Reaction=2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol; Xref=Rhea:RHEA:31451, ChEBI:CHEBI:17754, ChEBI:CHEBI:62237, ChEBI:CHEBI:64716; |
case not defined <Property:Membrane> or <Property:Membrane=1> | |
SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2> | |
SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
end case | |
SIMILARITY | Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily. |
Keywords
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case defined <Property:Membrane> and <Property:Membrane=2> | |
Cell inner membrane | |
end case | |
Cell membrane | |
Lipid biosynthesis | |
Lipid metabolism | |
Membrane | |
Phospholipid biosynthesis | |
Phospholipid metabolism | |
Transferase | |
Transmembrane | |
Transmembrane helix |
Gene Ontology
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GO:0016780; Molecular function:phosphotransferase activity, for other substituted phosphate groups |
GO:0008654; Biological process:phospholipid biosynthetic process |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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PROSITE | PS50035; PLD; 2; |
Pfam | PF13091; PLDc_2; 0-2; |
Pfam | PF13396; PLDc_N; 0-1; |
Pfam | PF00614; PLDc; 0-2; |
NCBIfam | TIGR04265; bac_cardiolipin; 1; |
General | Transmembrane; -; 2-3; |
Features
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From: CLSA_ECOLI (P0A6H8) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 224 | 224 | H | |||||||||
ACT_SITE | 226 | 226 | K | |||||||||
ACT_SITE | 231 | 231 | D | |||||||||
ACT_SITE | 404 | 404 | H | |||||||||
ACT_SITE | 406 | 406 | K | |||||||||
ACT_SITE | 411 | 411 | D |
Additional information
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Size range | 449-532 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | This HAMAP is now restricted to the ClsA sub-subfamily (Pseudomonadota). |