HAMAP rule MF_00394
General rule information
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Accession | MF_00394 |
Dates | 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 37) |
Name | NAD_Glyc3P_dehydrog |
Scope(s) |
Bacteria Archaea |
Template(s) | O29390 (GPDA_ARCFU); [ Recover all ] |
Triggered by |
HAMAP; MF_00394 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | GPDA |
Protein name | RecName: Full=Glycerol-3-phosphate dehydrogenase [NAD(P)+]; EC=1.1.1.94; AltName: Full=NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; |
Gene name | Name=gpsA; |
Comments
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CATALYTIC ACTIVITY | Reaction=NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH; Xref=Rhea:RHEA:11092, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57597, ChEBI:CHEBI:57642, ChEBI:CHEBI:57945; EC=1.1.1.94; |
CATALYTIC ACTIVITY | Reaction=NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH; Xref=Rhea:RHEA:11096, ChEBI:CHEBI:15378, ChEBI:CHEBI:57597, ChEBI:CHEBI:57642, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.94; |
SUBCELLULAR LOCATION | Cytoplasm. |
PATHWAY | Membrane lipid metabolism; glycerophospholipid metabolism. |
SIMILARITY | Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. |
Keywords
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Cytoplasm |
Lipid biosynthesis |
Lipid metabolism |
Phospholipid biosynthesis |
Phospholipid metabolism |
NAD |
Oxidoreductase |
Gene Ontology
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GO:0047952; Molecular function:glycerol-3-phosphate dehydrogenase [NAD(P)+] activity |
GO:0046167; Biological process:glycerol-3-phosphate biosynthetic process |
GO:0008654; Biological process:phospholipid biosynthetic process |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Pfam | PF07479; NAD_Gly3P_dh_C; 1; |
Pfam | PF01210; NAD_Gly3P_dh_N; 1; |
PIRSF | PIRSF000114; Glycerol-3-P_dh; 1; |
PRINTS | PR00077; GPDHDRGNASE; 1; |
PROSITE | PS00957; NAD_G3PDH; 1; |
Features
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From: GPDA_ECOLI (P0A6S7) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 12 | 17 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
|||||||||
BINDING | 259 | 260 | /ligand="substrate" | R-N | ||||||||
ACT_SITE | 195 | 195 | /note="Proton acceptor" | K | ||||||||
BINDING | 110 | 110 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
K | ||||||||
BINDING | 110 | 110 | /ligand="substrate" | K | ||||||||
BINDING | 143 | 143 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[AS] | ||||||||
BINDING | 259 | 259 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
R | ||||||||
BINDING | 285 | 285 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
E |
Additional information
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Size range | 297-369 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |