HAMAP rule MF_00578
General rule information
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Accession | MF_00578 |
Dates | 27-AUG-2002 (Created)
1-JUN-2023 (Last updated, Version 23) |
Name | Glu_cys_ligase |
Scope(s) |
Bacteria |
Template(s) | P0A6W9 (GSH1_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00578 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | GSH1 |
Protein name | RecName: Full=Glutamate--cysteine ligase; EC=6.3.2.2; AltName: Full=Gamma-ECS; Short=GCS; AltName: Full=Gamma-glutamylcysteine synthetase; |
Gene name | Name=gshA; |
Comments
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CATALYTIC ACTIVITY | Reaction=ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L- cysteine + H(+) + phosphate; Xref=Rhea:RHEA:13285, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:35235, ChEBI:CHEBI:43474, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=6.3.2.2; |
PATHWAY | Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. |
SIMILARITY | Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. |
Keywords
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Gene Ontology
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GO:0004357; Molecular function:glutamate-cysteine ligase activity |
GO:0006750; Biological process:glutathione biosynthetic process |
Cross-references
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Features
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Additional information
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Size range | 505-535 amino acids |
Related rules |
MF_00782 |
Fusion | Nter: None Cter: None |