HAMAP rule MF_00586
General rule information
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| Accession | MF_00586 |
| Dates | 21-OCT-2002 (Created)
1-JUN-2023 (Last updated, Version 24) |
| Name | GatD |
| Scope(s) |
Archaea |
| Template(s) | O26802 (GATD_METTH); [ Recover all ] |
| Triggered by |
HAMAP; MF_00586 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GATD |
| Protein name | RecName: Full=Glutamyl-tRNA(Gln) amidotransferase subunit D; Short=Glu-ADT subunit D; EC=6.3.5.-; |
| Gene name | Name=gatD; |
Comments
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| FUNCTION | Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. |
| CATALYTIC ACTIVITY | Reaction=ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate; Xref=Rhea:RHEA:17521, Rhea:RHEA-COMP:9681, Rhea:RHEA-COMP:9684, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359, ChEBI:CHEBI:78520, ChEBI:CHEBI:78521, ChEBI:CHEBI:456216; |
| SUBUNIT | Heterodimer of GatD and GatE. |
| SIMILARITY | Belongs to the asparaginase 1 family. GatD subfamily. |
Keywords
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Gene Ontology
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| GO:0050567; Molecular function:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity |
| GO:0006412; Biological process:translation |
Cross-references
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| Pfam | PF00710; Asparaginase; 1; |
| PRINTS | PR00139; ASNGLNASE; 1; |
| NCBIfam | TIGR00519; AsnASE_I; 1; |
| NCBIfam | TIGR02153; gatD_arch; 1; |
| PROSITE | PS00144; ASN_GLN_ASE_1; 1; |
| PROSITE | PS00917; ASN_GLN_ASE_2; 1; |
| PROSITE | PS51732; ASN_GLN_ASE_3; 1; |
Features
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| From: GATD_METTH (O26802) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 101 | 101 | T | |||||||||
| ACT_SITE | 177 | 177 | T | |||||||||
| ACT_SITE | 178 | 178 | D | |||||||||
| ACT_SITE | 254 | 254 | K | |||||||||
Additional information
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| Size range | 406-458 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |