HAMAP rule MF_00605
General rule information
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| Accession | MF_00605 |
| Dates | 29-NOV-2002 (Created)
13-OCT-2023 (Last updated, Version 30) |
| Name | TrmD |
| Scope(s) |
Bacteria |
| Template(s) | P0A873 (TRMD_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00605 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TRMD |
| Protein name | RecName: Full=tRNA (guanine-N(1)-)-methyltransferase; EC=2.1.1.228; AltName: Full=M1G-methyltransferase; AltName: Full=tRNA [GM37] methyltransferase; |
| Gene name | Name=trmD; |
Comments
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| FUNCTION | Specifically methylates guanosine-37 in various tRNAs. |
| CATALYTIC ACTIVITY | Reaction=guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)- methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:36899, Rhea:RHEA-COMP:10145, Rhea:RHEA-COMP:10147, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:73542, ChEBI:CHEBI:74269; EC=2.1.1.228; |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the RNA methyltransferase TrmD family. |
Keywords
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Gene Ontology
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| GO:0052906; Molecular function:tRNA (guanine(37)-N1)-methyltransferase activity |
| GO:0006400; Biological process:tRNA modification |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: TRMD_ECOLI (P0A873) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 133 | 138 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[ILVM]-G-[DN]-[YF]-[IV]-[ILVM] | ||||||||
| BINDING | 113 | 113 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
G | ||||||||
Additional information
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| Size range | 222-361 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: <Unknown> |