HAMAP rule MF_00767
General rule information
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Accession | MF_00767 |
Dates | 6-APR-2004 (Created)
1-JUN-2023 (Last updated, Version 26) |
Name | Arg_catab_AstE |
Scope(s) |
Bacteria Pseudomonadota |
Template(s) | P76215 (ASTE_ECOLI); Q7NU26 (ASTE_CHRVO); Q87Q40 (ASTE_VIBPA); [ Recover all ] |
Triggered by |
HAMAP; MF_00767 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | ASTE |
Protein name | RecName: Full=Succinylglutamate desuccinylase; EC=3.5.1.96; |
Gene name | Name=astE; |
Comments
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FUNCTION | Transforms N(2)-succinylglutamate into succinate and glutamate. |
CATALYTIC ACTIVITY | Reaction=H2O + N-succinyl-L-glutamate = L-glutamate + succinate; Xref=Rhea:RHEA:15169, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:30031, ChEBI:CHEBI:58763; EC=3.5.1.96; |
case <FTGroup:1> | |
COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
end case | |
PATHWAY | Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 5/5. |
SIMILARITY | Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily. |
Keywords
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Arginine metabolism | |
Hydrolase | |
case <FTGroup:1> | |
Zinc | |
Metal-binding | |
end case |
Gene Ontology
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GO:0016788; Molecular function:hydrolase activity, acting on ester bonds | |
case <FTGroup:1> | |
GO:0008270; Molecular function:zinc ion binding | |
end case | |
GO:0019544; Biological process:arginine catabolic process to glutamate |
Cross-references
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Pfam | PF04952; AstE_AspA; 1; |
PIRSF | PIRSF017020; AstE; 1; |
NCBIfam | TIGR03242; Arg_catab_astE; 1; |
Features
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From: ASTE_CHRVO (Q7NU26) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 214 | 214 | E | |||||||||
BINDING | 56 | 56 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
BINDING | 59 | 59 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
E | 1 | |||||||
BINDING | 149 | 149 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 |
Additional information
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Size range | 322-351 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |