HAMAP rule MF_01001
General rule information
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Accession | MF_01001 |
Dates | 7-FEB-2002 (Created)
1-JUN-2023 (Last updated, Version 25) |
Name | WecG_RffM |
Scope(s) |
Bacteria Enterobacterales |
Template(s) | P27836 (WECG_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01001 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | WECG |
Protein name | RecName: Full=UDP-N-acetyl-D-mannosaminuronic acid transferase; Short=UDP-ManNAcA transferase; EC=2.4.1.180; |
Gene name | Name=wecG; Synonyms=rffM; |
Comments
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FUNCTION | Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis. |
CATALYTIC ACTIVITY | Reaction=N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate = beta-D- ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP; Xref=Rhea:RHEA:28366, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:61495, ChEBI:CHEBI:62959, ChEBI:CHEBI:70731; EC=2.4.1.180; |
PATHWAY | Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis. |
SIMILARITY | Belongs to the glycosyltransferase 26 family. |
Keywords
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Gene Ontology
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GO:0047241; Molecular function:lipopolysaccharide N-acetylmannosaminouronosyltransferase activity |
GO:0009246; Biological process:enterobacterial common antigen biosynthetic process |
Cross-references
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Features
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Additional information
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Size range | 235-260 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |