HAMAP rule MF_01031
General rule information
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| Accession | MF_01031 |
| Dates | 6-SEP-2002 (Created)
1-JUN-2023 (Last updated, Version 30) |
| Name | LeuD_type1 |
| Scope(s) |
Bacteria |
| Template(s) | P04787 (LEUD1_SALTY); [ Recover all ] |
| Triggered by |
HAMAP; MF_01031 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | LEUD |
| Protein name | RecName: Full=3-isopropylmalate dehydratase small subunit; EC=4.2.1.33; AltName: Full=Alpha-IPM isomerase; Short=IPMI; AltName: Full=Isopropylmalate isomerase; |
| Gene name | Name=leuD; |
Comments
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| FUNCTION | Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. |
| CATALYTIC ACTIVITY | Reaction=(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate; Xref=Rhea:RHEA:32287, ChEBI:CHEBI:1178, ChEBI:CHEBI:35121; EC=4.2.1.33; |
| PATHWAY | Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4. |
| SUBUNIT | Heterodimer of LeuC and LeuD. |
| SIMILARITY | Belongs to the LeuD family. LeuD type 1 subfamily. |
Keywords
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Gene Ontology
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| GO:0003861; Molecular function:3-isopropylmalate dehydratase activity |
| GO:0009098; Biological process:leucine biosynthetic process |
Cross-references
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Features
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Additional information
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| Size range | 189-230 amino acids |
| Related rules |
MF_01032 |
| Fusion | Nter: None Cter: None |