HAMAP rule MF_01039
General rule information
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| Accession | MF_01039 |
| Dates | 12-DEC-2002 (Created)
1-JUN-2023 (Last updated, Version 41) |
| Name | PGAM_GpmA |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P62707 (GPMA_ECOLI); Q3JWH7 (GPMA_BURP1); P9WIC9 (GPMA_MYCTU); [ Recover all ] |
| Triggered by |
HAMAP; MF_01039 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GPMA |
| Protein name | RecName: Full=2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Short=BPG-dependent PGAM; Short=PGAM; Short=Phosphoglyceromutase; Short=dPGM; EC=5.4.2.11; |
| Gene name | Name=gpmA; |
Comments
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| FUNCTION | Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. |
| CATALYTIC ACTIVITY | Reaction=(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate; Xref=Rhea:RHEA:15901, ChEBI:CHEBI:58272, ChEBI:CHEBI:58289; EC=5.4.2.11; |
| PATHWAY | Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 3/5. |
| case <OC:Pseudomonadota> | |
| SUBUNIT | Homodimer. |
| end case | |
| SIMILARITY | Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. |
Keywords
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Gene Ontology
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| GO:0046538; Molecular function:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity |
| GO:0006094; Biological process:gluconeogenesis |
| GO:0006096; Biological process:glycolytic process |
Cross-references
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Features
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| From: GPMA_ECOLI (P62707) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 10 | 17 | /ligand="substrate" | R-H-G-x-S-x(2)-[NK] | ||||||||
| BINDING | 23 | 24 | /ligand="substrate" | [TS]-G | ||||||||
| BINDING | 89 | 92 | /ligand="substrate" | E-[RK]-x-Y | ||||||||
| BINDING | 116 | 117 | /ligand="substrate" | R-R | ||||||||
| BINDING | 185 | 186 | /ligand="substrate" | G-N | ||||||||
| ACT_SITE | 11 | 11 | /note="Tele-phosphohistidine intermediate" | H | ||||||||
| ACT_SITE | 89 | 89 | /note="Proton donor/acceptor" | E | ||||||||
| BINDING | 62 | 62 | /ligand="substrate" | R | ||||||||
| BINDING | 100 | 100 | /ligand="substrate" | K | ||||||||
| SITE | 184 | 184 | /note="Transition state stabilizer" | H | ||||||||
Additional information
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| Size range | 195-400 amino acids |
| Related rules |
MF_01040 |
| Fusion | Nter: None Cter: None |