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HAMAP rule MF_01082

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General rule information [?]

Accession MF_01082
Dates 26-SEP-2003 (Created)
1-JUN-2023 (Last updated, Version 29)
Name TruD
Scope(s) Bacteria
Archaea
Template(s) Q57261 (TRUD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01082 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TRUD
case <OC:Bacteria>
Protein name RecName: Full=tRNA pseudouridine synthase D;
                 EC=5.4.99.27;
AltName: Full=tRNA pseudouridine(13) synthase;
AltName: Full=tRNA pseudouridylate synthase D;
AltName: Full=tRNA-uridine isomerase D;
end case
case <OC:Archaea>
Protein name RecName: Full=Probable tRNA pseudouridine synthase D;
                 EC=5.4.99.27;
AltName: Full=tRNA pseudouridine(13) synthase;
AltName: Full=tRNA pseudouridylate synthase D;
AltName: Full=tRNA-uridine isomerase D;
end case
Gene name Name=truD;

Comments [?]

case <OC:Bacteria>
FUNCTIONResponsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
end case
case <OC:Archaea>
FUNCTIONCould be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
end case
CATALYTIC ACTIVITY Reaction=uridine(13) in tRNA = pseudouridine(13) in tRNA; Xref=Rhea:RHEA:42540, Rhea:RHEA-COMP:10105, Rhea:RHEA-COMP:10106, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.27;
SIMILARITYBelongs to the pseudouridine synthase TruD family.

Keywords [?]


Gene Ontology [?]

GO:0009982; Molecular function:pseudouridine synthase activity
GO:0031119; Biological process:tRNA pseudouridine synthesis

Cross-references [?]

Pfam PF01142; TruD; 1;
NCBIfam TIGR00094; TRNA_TruD_broad; 1;
PROSITE PS50984; TRUD; 1;
PROSITE PS01268; UPF0024; 1;

Features [?]

From: TRUD_ECOLI (Q57261)
Key From To Description Tag Condition FTGroup
ACT_SITE 80 80 /note="Nucleophile" D
case <OC:Enterobacterales>
BINDING 27 27 /ligand="substrate" F
BINDING 129 129 /ligand="substrate" N
BINDING 329 329 /ligand="substrate" F
end case

Additional information [?]

Size range 335-460 amino acids
Related rules None
Fusion Nter: None Cter: None



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