HAMAP rule MF_01117
General rule information
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| Accession | MF_01117 |
| Dates | 20-NOV-2003 (Created)
29-SEP-2022 (Last updated, Version 31) |
| Name | CDP_archaeol_synth |
| Scope(s) |
Archaea |
| Template(s) | O28534 (CDPAS_ARCFU); [ Recover all ] |
| Triggered by |
HAMAP; MF_01117 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CDPAS |
| Protein name | RecName: Full=CDP-archaeol synthase; EC=2.7.7.67; AltName: Full=CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase; |
| Gene name | Name=carS; |
Comments
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| FUNCTION | Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. |
| CATALYTIC ACTIVITY | Reaction=2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) = CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate; Xref=Rhea:RHEA:25690, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:58837, ChEBI:CHEBI:58838; EC=2.7.7.67; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| PATHWAY | Membrane lipid metabolism; glycerophospholipid metabolism. |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the CDP-archaeol synthase family. |
Keywords
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| Cell membrane |
| Lipid biosynthesis |
| Lipid metabolism |
| Magnesium |
| Membrane |
| Phospholipid biosynthesis |
| Phospholipid metabolism |
| Transferase |
| Transmembrane |
| Transmembrane helix |
Gene Ontology
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| GO:0016779; Molecular function:nucleotidyltransferase activity |
| GO:0046474; Biological process:glycerophospholipid biosynthetic process |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF01864; DUF46; 1; |
| General | Transmembrane; -; 2-5; |
Features
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Additional information
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| Size range | 149-240 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |