HAMAP rule MF_01234
General rule information
[?]
Accession | MF_01234 |
Dates | 24-MAR-2003 (Created)
19-NOV-2022 (Last updated, Version 27) |
Name | ManNAc_kinase |
Scope(s) |
Bacteria |
Template(s) | P45425 (NANK_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01234 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier | NANK |
Protein name | RecName: Full=N-acetylmannosamine kinase; EC=2.7.1.60; AltName: Full=ManNAc kinase; AltName: Full=N-acetyl-D-mannosamine kinase; |
Gene name | Name=nanK; |
Comments
[?]
FUNCTION | Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. |
CATALYTIC ACTIVITY | Reaction=an N-acyl-D-mannosamine + ATP = ADP + an N-acyl-D-mannosamine 6-phosphate + H(+); Xref=Rhea:RHEA:23832, ChEBI:CHEBI:15378, ChEBI:CHEBI:16062, ChEBI:CHEBI:30616, ChEBI:CHEBI:57666, ChEBI:CHEBI:456216; EC=2.7.1.60; |
PATHWAY | Amino-sugar metabolism; N-acetylneuraminate degradation; D- fructose 6-phosphate from N-acetylneuraminate: step 2/5. |
SUBUNIT | Homodimer. |
SIMILARITY | Belongs to the ROK (NagC/XylR) family. NanK subfamily. |
Keywords
[?]
Carbohydrate metabolism | |
Transferase | |
Kinase | |
ATP-binding | |
Nucleotide-binding | |
case <FTGroup:1> | |
Metal-binding | |
Zinc | |
end case |
Gene Ontology
[?]
GO:0005524; Molecular function:ATP binding | |
case <FTGroup:1> | |
GO:0008270; Molecular function:zinc ion binding | |
end case | |
GO:0009384; Molecular function:N-acylmannosamine kinase activity | |
GO:0005975; Biological process:carbohydrate metabolic process | |
GO:0006051; Biological process:N-acetylmannosamine metabolic process |
Cross-references
[?]
Features
[?]
From: NANK_ECOLI (P45425) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 5 | 12 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
|||||||||
BINDING | 132 | 139 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
|||||||||
BINDING | 156 | 156 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
BINDING | 166 | 166 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
BINDING | 168 | 168 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
BINDING | 173 | 173 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 |
Additional information
[?]
Size range | 287-300 amino acids |
Related rules |
None |
Fusion | Nter: MF_01235 (nanE) Cter: None |