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HAMAP rule MF_01290

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General rule information [?]

Accession MF_01290
Dates 3-OCT-2008 (Created)
19-NOV-2022 (Last updated, Version 14)
Name KDR_aldolase
Scope(s) Bacteria
Enterobacterales
Template(s) P76469 (RHMA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01290 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RHMA
Protein name RecName: Full=2-keto-3-deoxy-L-rhamnonate aldolase;
                 Short=KDR aldolase;
                 EC=4.1.2.53;
AltName: Full=2-dehydro-3-deoxyrhamnonate aldolase;
Gene name Name=rhmA;

Comments [?]

FUNCTIONCatalyzes the reversible retro-aldol cleavage of 2-keto-3- deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde.
CATALYTIC ACTIVITY Reaction=2-dehydro-3-deoxy-L-rhamnonate = (S)-lactaldehyde + pyruvate; Xref=Rhea:RHEA:25784, ChEBI:CHEBI:15361, ChEBI:CHEBI:18041, ChEBI:CHEBI:58371; EC=4.1.2.53;
case <FTGroup:1>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
end case
SUBUNITHomohexamer.
SIMILARITYBelongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily.

Keywords [?]

Lyase
case <FTGroup:1>
Magnesium
Metal-binding
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0000287; Molecular function:magnesium ion binding
end case
GO:0016832; Molecular function:aldehyde-lyase activity

Cross-references [?]

Pfam PF03328; HpcH_HpaI; 1;

Features [?]

From: RHMA_ECOLI (P76469)
Key From To Description Tag Condition FTGroup
ACT_SITE 49 49 /note="Proton acceptor" H
BINDING 153 153 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
E 1
BINDING 179 179 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
D 1
BINDING 151 151 /ligand="substrate" Q
BINDING 178 178 /ligand="substrate" A
BINDING 179 179 /ligand="substrate" D
SITE 74 74 /note="Transition state stabilizer" R
SITE 88 88 /note="Increases basicity of active site His" D

Additional information [?]

Size range 267-267 amino acids
Related rules None
Fusion Nter: None Cter: None



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