HAMAP rule MF_01293
General rule information
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| Accession | MF_01293 |
| Dates | 5-NOV-2008 (Created)
1-JUN-2023 (Last updated, Version 14) |
| Name | TagBP_aldolase_KbaY |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P0AB74 (KBAY_ECOLI); Q9KIP8 (KBAY_ECOLX); [ Recover all ] |
| Triggered by |
HAMAP; MF_01293 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | KBAY |
| Protein name | RecName: Full=D-tagatose-1,6-bisphosphate aldolase subunit KbaY; Short=TBPA; Short=TagBP aldolase; EC=4.1.2.40; AltName: Full=D-tagatose-bisphosphate aldolase class II; AltName: Full=Ketose 1,6-bisphosphate aldolase class II; AltName: Full=Tagatose-bisphosphate aldolase; |
| Gene name | Name=kbaY; |
Comments
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| FUNCTION | Catalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires KbaZ subunit for full activity and stability. |
| CATALYTIC ACTIVITY | Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3- phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948, ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40; |
| case <FTGroup:1> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| end case | |
| PATHWAY | Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6- phosphate: step 2/2. |
| SUBUNIT | Homotetramer. Forms a complex with KbaZ. |
| SIMILARITY | Belongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase KbaY subfamily. |
Keywords
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| Lyase | |
| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
| GO:0009025; Molecular function:tagatose-bisphosphate aldolase activity | |
| GO:0005975; Biological process:carbohydrate metabolic process | |
Cross-references
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| PROSITE | PS00602; ALDOLASE_CLASS_II_1; 1; |
| PROSITE | PS00806; ALDOLASE_CLASS_II_2; 1; |
| Pfam | PF01116; F_bP_aldolase; 1; |
| NCBIfam | TIGR00167; CbbA; 1; |
| NCBIfam | TIGR01858; Tag_bisphos_ald; 1; |
Features
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| From: KBAY_ECOLI (P0AB74) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 230 | 233 | /ligand="dihydroxyacetone phosphate" /ligand_id="ChEBI:CHEBI:57642" |
N-x-A-T | ||||||||
| BINDING | 209 | 211 | /ligand="dihydroxyacetone phosphate" /ligand_id="ChEBI:CHEBI:57642" |
G-x-S | ||||||||
| ACT_SITE | 82 | 82 | /note="Proton donor" | D | ||||||||
| BINDING | 83 | 83 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
| BINDING | 180 | 180 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
| BINDING | 208 | 208 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
| BINDING | 181 | 181 | /ligand="dihydroxyacetone phosphate" /ligand_id="ChEBI:CHEBI:57642" |
G | ||||||||
Additional information
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| Size range | 286-292 amino acids |
| Related rules |
MF_01294 |
| Fusion | Nter: None Cter: None |
| Comments | Subunit kbaZ is described in MF_01295. In some enterobacteria, a second D-tagatose-1,6-bisphosphate aldolase is present: gatYZ (MF_01294 and MF_01296). |