HAMAP rule MF_01488
General rule information
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| Accession | MF_01488 |
| Dates | 16-JAN-2014 (Created)
14-DEC-2023 (Last updated, Version 13) |
| Name | RecD2 |
| Scope(s) |
Bacteria Actinomycetota Chlamydiota Chlorobiota Chloroflexota Cyanobacteriota Deinococcota Bacillota Pseudomonadota Synergistota Mycoplasmatota |
| Template(s) | Q9RT63 (RECD2_DEIRA); O34481 (RECD2_BACSU); [ Recover all ] |
| Triggered by |
HAMAP; MF_01488 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | RECD2 |
| RecName: Full=ATP-dependent RecD2 DNA helicase;<br /> EC=<a href="https://enzyme.expasy.org/EC/5.6.2.3">5.6.2.3</a>;<br /> AltName: Full=DNA 5'-3' helicase subunit RecD2; | |
| Gene name | Name=recD2; |
Comments
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| FUNCTION | DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity. |
| CATALYTIC ACTIVITY | Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand.; EC=5.6.2.3; |
| CATALYTIC ACTIVITY | Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.3; |
| SIMILARITY | Belongs to the RecD family. RecD2 subfamily. |
Keywords
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| case <FT:1> | |
| ATP-binding | |
| Nucleotide-binding | |
| end case | |
| DNA-binding | |
| <a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a> | |
| Hydrolase | |
| Isomerase | |
Gene Ontology
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| GO:0043139; Molecular function:5'-3' DNA helicase activity | |
| case <FT:1> | |
| GO:0005524; Molecular function:ATP binding | |
| end case | |
| GO:0003677; Molecular function:DNA binding | |
Cross-references
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Features
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| From: RECD2_DEIRA (Q9RT63) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 363 | 367 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-[TMVKC]-G-K-[ST] | ||||||||
Additional information
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| Size range | 688-865 amino acids |
| Related rules |
MF_01487 |
| Fusion | Nter: None Cter: None |
| Comments | The RecD2 helicase is not associated with RecB and RecC, although a few organisms have both genes. Its physiological role varies in the few bacteria where it has been characterized. |