HAMAP rule MF_01614
General rule information
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| Accession | MF_01614 |
| Dates | 1-JUN-2005 (Created)
19-NOV-2022 (Last updated, Version 19) |
| Name | NamA |
| Scope(s) |
Bacteria Bacillales Eubacteriales |
| Template(s) | P54550 (NAMA_BACSU); [ Recover all ] |
| Triggered by |
HAMAP; MF_01614 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NAMA |
| Protein name | RecName: Full=NADPH dehydrogenase; EC=1.6.99.1; |
| Gene name | Name=namA; |
Comments
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| FUNCTION | Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes. |
| CATALYTIC ACTIVITY | Reaction=A + H(+) + NADPH = AH2 + NADP(+); Xref=Rhea:RHEA:13149, ChEBI:CHEBI:13193, ChEBI:CHEBI:15378, ChEBI:CHEBI:17499, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.6.99.1; |
| COFACTOR | Name=FMN; Xref=ChEBI:CHEBI:58210; |
| SUBUNIT | Homotetramer. |
| SIMILARITY | Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily. |
Keywords
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Gene Ontology
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| GO:0003959; Molecular function:NADPH dehydrogenase activity |
| GO:0010181; Molecular function:FMN binding |
| GO:0050661; Molecular function:NADP binding |
Cross-references
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| Pfam | PF00724; Oxidored_FMN; 1; |
Features
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| From: NAMA_BACSU (P54550) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 23 | 26 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
[SP]-P-M-C | ||||||||
| BINDING | 307 | 308 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
[AG]-R | ||||||||
| BINDING | 164 | 167 | /ligand="substrate" | H-x-x-H | ||||||||
| BINDING | 28 | 28 | /ligand="substrate" | Y | ||||||||
| BINDING | 60 | 60 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
A | ||||||||
| BINDING | 102 | 102 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
Q | ||||||||
| BINDING | 215 | 215 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
R | ||||||||
Additional information
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| Size range | 337-346 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |