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HAMAP rule MF_01618

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General rule information [?]

Accession MF_01618
Dates 11-NOV-2005 (Created)
1-JUN-2023 (Last updated, Version 20)
Name FadI
Scope(s) Bacteria
Gammaproteobacteria
Template(s) P76503 (FADI_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01618 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FADI
Protein name RecName: Full=3-ketoacyl-CoA thiolase;
                 EC=2.3.1.16;
AltName: Full=ACSs;
AltName: Full=Acetyl-CoA acyltransferase;
AltName: Full=Acyl-CoA ligase;
AltName: Full=Beta-ketothiolase;
AltName: Full=Fatty acid oxidation complex subunit beta;
Gene name Name=fadI;

Comments [?]

FUNCTIONCatalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
CATALYTIC ACTIVITY Reaction=acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA; Xref=Rhea:RHEA:21564, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:58342, ChEBI:CHEBI:90726; EC=2.3.1.16;
PATHWAYLipid metabolism; fatty acid beta-oxidation.
SUBUNITHeterotetramer of two alpha chains (FadJ) and two beta chains (FadI).
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the thiolase-like superfamily. Thiolase family.

Keywords [?]


Gene Ontology [?]

GO:0003988; Molecular function:acetyl-CoA C-acyltransferase activity
GO:0006631; Biological process:fatty acid metabolic process
GO:0016042; Biological process:lipid catabolic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

PROSITE PS00098; THIOLASE_1; 1;
PROSITE PS00737; THIOLASE_2; 1;
PROSITE PS00099; THIOLASE_3; 1;
Pfam PF02803; Thiolase_C; 1;
Pfam PF00108; Thiolase_N; 1;
NCBIfam TIGR01930; AcCoA-C-Actrans; 1;
NCBIfam TIGR02446; FadI; 1;

Features [?]

From: FADI_ECOLI (P76503)
Key From To Description Tag Condition FTGroup
ACT_SITE 99 99 /note="Acyl-thioester intermediate" C
ACT_SITE 392 392 /note="Proton acceptor" H
ACT_SITE 422 422 /note="Proton acceptor" C

Additional information [?]

Size range 435-442 amino acids
Related rules None
Fusion Nter: None Cter: None



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