HAMAP rule MF_01688
General rule information
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| Accession | MF_01688 |
| Dates | 8-APR-2009 (Created)
1-JUN-2023 (Last updated, Version 19) |
| Name | Biphenyl_BphD |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P47229 (BPHD_PARXL); [ Recover all ] |
| Triggered by |
HAMAP; MF_01688 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | BPHD |
| Protein name | RecName: Full=2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Short=HOPDA hydrolase; EC=3.7.1.8; AltName: Full=2,6-dioxo-6-phenylhexa-3-enoate hydrolase; |
| Gene name | Name=bphD; |
Comments
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| FUNCTION | Catalyzes an unusual C-C bond hydrolysis of 2-hydroxy-6-oxo- 6-phenylhexa-2,4-dienoic acid (HOPDA) to produce benzoic acid and 2- hydroxy-2,4-pentadienoic acid (HPD). |
| CATALYTIC ACTIVITY | Reaction=2,6-dioxo-6-phenylhexa-3-enoate + H2O = 2-oxopent-4-enoate + benzoate + H(+); Xref=Rhea:RHEA:17161, ChEBI:CHEBI:11641, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16150, ChEBI:CHEBI:64675; EC=3.7.1.8; |
| PATHWAY | Xenobiotic degradation; biphenyl degradation; 2-hydroxy-2,4- pentadienoate and benzoate from biphenyl: step 4/4. |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the AB hydrolase superfamily. BphD family. |
Keywords
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Gene Ontology
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| GO:0018771; Molecular function:2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity |
| GO:0019439; Biological process:aromatic compound catabolic process |
Cross-references
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Features
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| From: BPHD_PARXL (P47229) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 42 | 43 | /ligand="substrate" | G-G | ||||||||
| ACT_SITE | 112 | 112 | S | |||||||||
| ACT_SITE | 265 | 265 | /note="Proton acceptor" | H | ||||||||
| BINDING | 51 | 51 | /ligand="substrate" | N | ||||||||
| BINDING | 111 | 111 | /ligand="substrate" | [KN] | ||||||||
| BINDING | 180 | 180 | /ligand="substrate" | [ST] | ||||||||
| BINDING | 190 | 190 | /ligand="substrate" | R | ||||||||
| BINDING | 266 | 266 | /ligand="substrate" | W | ||||||||
| SITE | 112 | 112 | /note="Transition state stabilizer" | S | ||||||||
Additional information
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| Size range | 286-286 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |