HAMAP rule MF_01703
General rule information
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| Accession | MF_01703 |
| Dates | 11-OCT-2004 (Created)
1-JUN-2023 (Last updated, Version 23) |
| Name | ABC_ATPase_TM_MsbA |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P60752 (MSBA_ECOLI); [ Recover all ] |
| Triggered by |
PROSITE; PS51239 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MSBA |
| Protein name | RecName: Full=ATP-dependent lipid A-core flippase; EC=7.5.2.6; AltName: Full=Lipid A export ATP-binding/permease protein MsbA; |
| Gene name | Name=msbA; |
Comments
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| FUNCTION | Involved in lipopolysaccharide (LPS) biosynthesis. Translocates lipid A-core from the inner to the outer leaflet of the inner membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. |
| CATALYTIC ACTIVITY | Reaction=ATP + H2O + lipid A-core oligosaccharideSide 1 = ADP + phosphate + lipid A-core oligosaccharideSide 2.; EC=7.5.2.6; |
| SUBUNIT | Homodimer. |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| end case | |
| DOMAIN | In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused. |
| SIMILARITY | Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. |
Keywords
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| ATP-binding | |
| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Cell membrane | |
| <a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a> | |
| Lipid transport | |
| Membrane | |
| Nucleotide-binding | |
| Transmembrane | |
| Transmembrane helix | |
| Transport | |
Gene Ontology
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| GO:0006869; Biological process:lipid transport | |
| GO:0034040; Molecular function:ATPase-coupled lipid transmembrane transporter activity | |
| case <OCellular component:Bacteria> | |
| GO:0005886; Cellular component:plasma membrane | |
| end case | |
Cross-references
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| Pfam | PF00005; ABC_tran; 1; |
| Pfam | PF00664; ABC_membrane; 1; |
| NCBIfam | TIGR02203; MsbA_lipidA; 1; |
| PROSITE | PS50929; ABC_TM1F; 1; |
| PROSITE | PS00211; ABC_TRANSPORTER_1; 1; |
| PROSITE | PS50893; ABC_TRANSPORTER_2; 1; |
| General | Transmembrane; -; 5-6; |
Features
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| # Fix case/else syntax |
Additional information
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| Size range | 572-675 amino acids |
| Related rules |
PRU01700 |
| Fusion | Nter: None Cter: None |