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HAMAP rule MF_01967

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General rule information [?]

Accession MF_01967
Dates 2-APR-2012 (Created)
19-NOV-2022 (Last updated, Version 11)
Name Sirtuin_ClassII
Scope(s) Bacteria
Template(s) Q9Y6E7 (SIR4_HUMAN); [ Recover all ]
Triggered by
case c? <OC:Bacteria>
HAMAP; MF_01967 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NPD
Protein name RecName: Full=NAD-dependent protein deacetylase;
                 EC=2.3.1.286;
AltName: Full=Regulatory protein SIR2 homolog;
Gene name Name=cobB;

Comments [?]

FUNCTIONNAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
CATALYTIC ACTIVITY Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:43636, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:61930, ChEBI:CHEBI:83767; EC=2.3.1.286;
case <FTGroup:1>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
end case
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the sirtuin family. Class II subfamily.

Keywords [?]

Cytoplasm
NAD
case <FTGroup:1>
Metal-binding
Zinc
end case
Transferase

Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm
GO:0034979; Molecular function:NAD-dependent protein deacetylase activity
GO:0070403; Molecular function:NAD+ binding
GO:0006476; Biological process:protein deacetylation
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case

Cross-references [?]

PROSITE PS50305; SIRTUIN; 1;
Pfam PF02146; SIR2; 1;

Features [?]

From: SIR4_HUMAN (Q9Y6E7)
Key From To Description Tag Condition FTGroup
BINDING 62 82 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
G-A-G-x-S-T-x-x-G-[IV]-P-D-Y-R-x(7)
BINDING 143 146 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
Q-N-V-D
BINDING 260 262 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
G-[ST]-S
BINDING 286 288 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
N-x-G
ACT_SITE 161 161 /note="Proton acceptor" H
BINDING 169 169 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
C 1
BINDING 172 172 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
C 1
BINDING 220 220 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
C 1
BINDING 223 223 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
C 1
BINDING 304 304 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"

Additional information [?]

Size range 273-373 amino acids
Related rules MF_01121
MF_01968
Fusion Nter: None Cter: None



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