HAMAP rule MF_02208
General rule information
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| Accession | MF_02208 |
| Dates | 21-JAN-2019 (Created)
1-JUN-2023 (Last updated, Version 6) |
| Name | MurD2_subfam |
| Scope(s) |
Bacteria |
| Template(s) | Q2P5V2 (MURD2_XANOM); C4RJF7 (MURD2_MICS3); A4X981 (MURD2_SALTO); [ Recover all ] |
| Triggered by |
HAMAP; MF_02208 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MURD2 |
| Protein name | RecName: Full=UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase; EC=6.3.2.53; AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-L-glutamate synthetase; Short=UDP-MurNAc-L-Ala-L-Glu synthetase; |
| Gene name | Name=murD2; |
Comments
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| FUNCTION | Cell wall formation. Catalyzes the addition of L-glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine. |
| CATALYTIC ACTIVITY | Reaction=ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L- glutamate; Xref=Rhea:RHEA:58816, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:83898, ChEBI:CHEBI:142725, ChEBI:CHEBI:456216; EC=6.3.2.53; |
| PATHWAY | Cell wall biogenesis; peptidoglycan biosynthesis. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the MurCDEF family. MurD2 subfamily. |
Keywords
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| ATP-binding |
| Cell cycle |
| Cell division |
| Cell shape |
| Cell wall biogenesis/degradation |
| Cytoplasm |
| Ligase |
| Nucleotide-binding |
| Peptidoglycan synthesis |
Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0016881; Molecular function:acid-amino acid ligase activity |
| GO:0009252; Biological process:peptidoglycan biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: MURD2_XANOM (Q2P5V2) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 122 | 128 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-[TS]-[KN]-G-K-[ST]-T | ||||||||
Additional information
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| Size range | 400-500 amino acids |
| Related rules |
MF_00639 |
| Fusion | Nter: None Cter: None |