HAMAP rule MF_03177

General rule information [?]

Accession	MF_03177
Dates	31-JUL-2013 (Created) 19-NOV-2022 (Last updated, Version 9)
Name	RRM3
Scope(s)	Eukaryota Saccharomycetales
Template(s)	P38766 (RRM3_YEAST); [ Recover all ]
Triggered by	HAMAP; MF_03177 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	RRM3
RecName: Full=ATP-dependent DNA helicase RRM3;<br />                  EC=<a href="https://enzyme.expasy.org/EC/3.6.4.12">3.6.4.12</a>;<br /> AltName: Full=rDNA recombination mutation protein 3;
Gene name	Name=RRM3;

Comments [?]

FUNCTION	5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein- DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Plays also a role in mtDNA replication. Has G- quadruplex (G4) unwinding activity and can suppress G4-induced genome instability when PIF1 levels are low.
CATALYTIC ACTIVITY	Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
SUBCELLULAR LOCATION	Nucleus. Chromosome, telomere.
SIMILARITY	Belongs to the helicase family. PIF1 subfamily.

Keywords [?]

ATP-binding
Chromosome
DNA damage
DNA repair
DNA-binding
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a>
Hydrolase
Nucleotide-binding
Nucleus
Telomere

Gene Ontology [?]

GO:0005657; Cellular component:replication fork

GO:0000781; Cellular component:chromosome, telomeric region

GO:0005524; Molecular function:ATP binding

GO:0043139; Molecular function:5'-3' DNA helicase activity

GO:0051880; Molecular function:G-quadruplex DNA binding

GO:0006260; Biological process:DNA replication

GO:0006281; Biological process:DNA repair

GO:0000002; Biological process:mitochondrial genome maintenance

Cross-references [?]

Pfam	PF05970; PIF1; 1;

Features [?]

From: RRM3_YEAST (P38766)

Key

From

Description

Tag

Condition

FTGroup

BINDING

254

261

/ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"

G-x-A-G-T-G-K-S

DNA_BIND

682

701

[QH]-x-Y-V-A-[LI]-S-R-[AV]-x(5)-[LIV]-[QERH]-[LIV]-x(2)-F

Additional information [?]