HAMAP rule MF_04013
General rule information
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| Accession | MF_04013 |
| Dates | 16-MAR-2016 (Created)
3-MAY-2022 (Last updated, Version 6) |
| Name | HSV_TRM3 |
| Scope(s) |
Viruses Herpesviridae |
| Template(s) | P04295 (TRM3_HHV11); [ Recover all ] |
| Triggered by |
HAMAP; MF_04013 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TRM3 |
| Protein name | RecName: Full=Tripartite terminase subunit 3; EC=3.1.-.-; AltName: Full=Terminase large subunit; |
| Gene name | Name=TRM3; |
Comments
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| FUNCTION | Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM2 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM3 carries an RNase H-like nuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes. |
| SUBUNIT | Interacts with the terminase subunits TRM1 and TRM2. Interacts with portal protein. |
| SUBCELLULAR LOCATION | Host nucleus. Note=Responsible for the nuclear localization of the two others subunits TRM1 and TRM2. |
| SIMILARITY | Belongs to the herpesviridae TRM3 protein family. |
Keywords
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Gene Ontology
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| GO:0042025; Cellular component:host cell nucleus |
| GO:0051276; Biological process:chromosome organization |
| GO:0019076; Biological process:viral release from host cell |
| GO:0004518; Molecular function:nuclease activity |
Cross-references
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Features
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| From: TRM3_HHV11 (P04295) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Alphaherpesvirinae> | ||||||||||||
| MOTIF | 183 | 189 | /note="Nuclear localization signal" | |||||||||
| end case | ||||||||||||
| MOTIF | 258 | 265 | /note="Walker A motif" | [VI]-P-R-R-H-G-K-T | ||||||||
| MOTIF | 352 | 357 | /note="Walker B motif" | [LI]-L-[FYLI]-V-D-E | ||||||||
| ACT_SITE | 357 | 357 | /note="For ATPase activity" | E | ||||||||
| ACT_SITE | 509 | 509 | /note="For nuclease activity" | D | ||||||||
| ACT_SITE | 581 | 581 | /note="For nuclease activity" | E | ||||||||
| ACT_SITE | 707 | 707 | /note="For nuclease activity" | D | ||||||||
Additional information
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| Size range | 660-747 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |