HAMAP rule MF_04062
General rule information
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| Accession | MF_04062 |
| Dates | 24-MAR-2017 (Created)
29-SEP-2022 (Last updated, Version 9) |
| Name | INV_PB2 |
| Scope(s) |
Viruses Orthomyxoviridae |
| Template(s) | P03428 (PB2_I34A1); [ Recover all ] |
| Triggered by |
HAMAP; MF_04062 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PB2 |
| Protein name | RecName: Full=Polymerase basic protein 2; AltName: Full=RNA-directed RNA polymerase subunit P3; |
| Gene name | Name=PB2; |
Comments
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| case <OC:Alphainfluenzavirus> and <FTTag:Hostd> | |
| FUNCTION | Plays an essential role in transcription initiation and cap- stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7- methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS. |
| SUBUNIT | Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus). Interacts (via N- terminus) with host MAVS (via N-terminus); this interaction inhibits host innate immune response. |
| SUBCELLULAR LOCATION | Virion. Host nucleus. Host mitochondrion. |
| else case <OC:Alphainfluenzavirus> and not <FTTag:Hostd> | |
| FUNCTION | Plays an essential role in transcription initiation and cap- stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7- methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. |
| SUBUNIT | Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus). |
| SUBCELLULAR LOCATION | Virion. Host nucleus. |
| else | |
| FUNCTION | Plays an essential role in transcription initiation and cap- stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds a wide range of cap structures of target pre-RNAs which are subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. |
| SUBUNIT | Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus). |
| SUBCELLULAR LOCATION | Virion. Host nucleus. |
| end case | |
| SIMILARITY | Belongs to the influenza viruses PB2 family. |
Keywords
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Gene Ontology
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| case <FTTag:Hostd> | |
| GO:0039545; Biological process:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity | |
| GO:0033650; Cellular component:host cell mitochondrion | |
| end case | |
| GO:0042025; Cellular component:host cell nucleus | |
| GO:0044423; Cellular component:virion component | |
| GO:0003723; Molecular function:RNA binding | |
| GO:0003968; Molecular function:RNA-dependent RNA polymerase activity | |
| GO:0006370; Biological process:7-methylguanosine mRNA capping | |
| GO:0075526; Biological process:cap snatching | |
| GO:0039523; Biological process:suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity | |
| GO:0006351; Biological process:DNA-templated transcription | |
| GO:0019083; Biological process:viral transcription | |
Cross-references
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| Pfam | PF00604; Flu_PB2; 1; |
Features
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| From: PB2_I34A1 (P03428) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOTIF | 736 | 739 | /note="Nuclear localization signal" | K-R-K-R | ||||||||
| case <OC:Alphainfluenzavirus> | ||||||||||||
| SITE | 627 | 627 | /note="Mammalian adaptation" | Hostd | K | |||||||
| SITE | 627 | 627 | /note="Avian adaptation" | HostA | E | |||||||
| end case | ||||||||||||
Additional information
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| Size range | 759-774 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |